Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.

@article{Sauter1992BindingOI,
  title={Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.},
  author={Nicholas K. Sauter and Judith E. Hanson and Gary D Glick and Judith H Brown and Robert L. Crowther and Sung Jin Park and John J. Skehel and Don C. Wiley},
  journal={Biochemistry},
  year={1992},
  volume={31 40},
  pages={9609-21}
}
The interaction between influenza virus hemagglutinin and its cell-surface receptor, 5-N-acetylneuraminic acid (sialic acid), was probed by the synthesis of 12 sialic acid analogs, including derivatives at the 2-carboxylate, 5-acetamido, 4-, 7-, and 9-hydroxyl, and glycosidic positions. The equilibrium dissociation constants of these analogs were determined by nuclear magnetic resonance spectroscopy. Ligand modifications that reduced or abolished binding included the replacement of the 2… CONTINUE READING