Binding of hydralazine and a major metabolite, pyruvate hydrazone, to rat plasma protein and human serum albumin.

@article{Ogiso1984BindingOH,
  title={Binding of hydralazine and a major metabolite, pyruvate hydrazone, to rat plasma protein and human serum albumin.},
  author={T. Ogiso and M. Iwaki},
  journal={Chemical \& pharmaceutical bulletin},
  year={1984},
  volume={32 8},
  pages={
          3155-63
        }
}
  • T. Ogiso, M. Iwaki
  • Published 1984
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
The interaction of hydralazine (HP) and a major metabolite, pyruvate hydrazone (HPH), with rat plasma protein or human serum albumin (HSA) was studied both in vivo (by the ultrafiltration method) and in vitro (at 20 and 30°C, by the equilibrium dialysis method). The binding of HP and HPH to plasma proteins was fairly high (96.0 and 81.7%. respectively) after i.v. administration to rats. HPH, which had an association constant higher than HP, was found to interact with a single class of site on… Expand
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