Binding of human immunodeficiency virus type I (HIV-1) gp120 to galactosylceramide (GalCer): relationship to the V3 loop.

@article{Cook1994BindingOH,
  title={Binding of human immunodeficiency virus type I (HIV-1) gp120 to galactosylceramide (GalCer): relationship to the V3 loop.},
  author={D. G. Cook and Jacques Fantini and Steven L Spitalnik and Francisco Gonz{\'a}lez-Scarano},
  journal={Virology},
  year={1994},
  volume={201 2},
  pages={206-14}
}
The primary receptor for the human immunodeficiency virus (HIV) is the CD4 molecule. However, a large body of evidence has demonstrated that some cells that do not express the CD4 receptor can be infected by HIV-1 and HIV-2, indicating that an alternative mechanism of infection must exist for some cell types. Recently it was reported that antibodies against the glycosphingolipid, galactosylceramide (Gal beta 1-1'Cer;GalCer), blocked infection of several CD4 negative cell lines derived from the… CONTINUE READING

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