Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

@article{Strittmatter1993BindingOH,
  title={Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.},
  author={Warren J. Strittmatter and Karl H. Weisgraber and David Y. C. Huang and Lenny Dong and Guy Salvesen and Margaret A. Pericak-Vance and Donald E. Schmechel and Ann M Saunders and Dmitry Goldgaber and A. D. Roses},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 17},
  pages={8098-102}
}
Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of Alzheimer disease. Late-onset familial and sporadic Alzheimer disease patients have an increased frequency of one of the three common apoE alleles, epsilon 4, suggesting apoE4 is associated with increased susceptibility to disease. To follow up on this suggestion, we compared the binding of synthetic… CONTINUE READING
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