Binding of human GII.4 norovirus virus-like particles to carbohydrates of romaine lettuce leaf cell wall materials.

@article{Esseili2012BindingOH,
  title={Binding of human GII.4 norovirus virus-like particles to carbohydrates of romaine lettuce leaf cell wall materials.},
  author={Malak A Esseili and Qiuhong Wang and Linda J. Saif},
  journal={Applied and environmental microbiology},
  year={2012},
  volume={78 3},
  pages={786-94}
}
Norovirus (NoV) genogroup II genotype 4 (GII.4) strains are the dominant cause of the majority of food-borne outbreaks, including those that involve leafy greens, such as lettuce. Since human NoVs use carbohydrates of histo-blood group antigens as receptors/coreceptors, we examined the role of carbohydrates in the attachment of NoV to lettuce leaves by using virus-like particles (VLPs) of a human NoV/GII.4 strain. Immunofluorescence analysis showed that the VLPs attached to the leaf surface… CONTINUE READING
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