Binding of heat shock factor to and transcriptional activation of heat shock genes in Drosophila.

@article{Fernandes1995BindingOH,
  title={Binding of heat shock factor to and transcriptional activation of heat shock genes in Drosophila.},
  author={Mike Fernandes and Hua Xiao and John T Lis},
  journal={Nucleic acids research},
  year={1995},
  volume={23 23},
  pages={
          4799-804
        }
}
Heat shock factor (HSF) binds to heat shock elements (HSEs) and the binding can be highly cooperative. Here we report an analysis of binding of Drosophila HSF to both native and synthetic heat shock regulatory regions. We find that cooperative binding of HSF requires close proximity, rather than helical alignment, of HSEs. Two or more trimeric HSEs organized as contiguous 5 bp units show much higher levels of cooperativity than multiple but separated HSEs. We discuss these in vitro observations… CONTINUE READING
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