Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein.

@article{Pinkoski1996BindingOG,
  title={Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein.},
  author={Michael J. Pinkoski and Ulrike Winkler and Dorothy Hudig and Robert Chris Bleackley},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 17},
  pages={10225-9}
}
Granzyme B (cytotoxic cell proteinase 1) is a serine proteinase that has been implicated in cytotoxic T lymphocyte-induced apoptosis. In order to understand how granzyme B is involved in mechanisms of target cell destruction, characterization and identification of substrates are required. We have developed an in situ binding assay using permeabilized cells… CONTINUE READING