Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.

@article{Rosnet2004BindingOF,
  title={Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.},
  author={Olivier Rosnet and Carla E Blanco-Betancourt and Karine Grivel and Kirsten Richter and Claudine Schiff},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 11},
  pages={10228-36}
}
The VpreB3 gene product was first characterized as an immunoglobulin (Ig) mu heavy chain-binding protein in mouse precursor B (pre-B) cells. Although its function is unknown, it has been proposed to participate in the assembly and transport of the pre-B cell receptor. We have identified a VpreB3 orthologous gene in chicken that is located close to the immunoglobulin light chain (LC) gene cluster and specifically expressed in the bursa of Fabricius. By overexpressing VpreB3 in the DT40 IgM… CONTINUE READING

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Immunoglobulin Light Chain Secretion 10236 by gest on D ecem er 24

A. Bertolotti, Y. Zhang, L. M. Hendershot, H. P. Harding, D. Ron
Nat. Cell Biol • 2000
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