Binding of ethidium to the nucleosome core particle. 2. Internal and external binding modes.

@article{McMurray1991BindingOE,
  title={Binding of ethidium to the nucleosome core particle. 2. Internal and external binding modes.},
  author={Cynthia T McMurray and Eric W. Small and Kensal E van Holde},
  journal={Biochemistry},
  year={1991},
  volume={30 23},
  pages={5644-52}
}
We have previously reported that the binding of ethidium bromide to the nucleosome core particle results in a stepwise dissociation of the structure which involves the initial release of one copy each of H2A and H2B (McMurray & van Holde, 1986). In this report, we have examined the absorbance and fluorescence properties of intercalated and outside bound forms of ethidium bromide. From these properties, we have measured the extent of external, electrostatic binding of the dye versus internal… CONTINUE READING

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