Binding of doxorubicin-conjugated transferrin to U937 cells.

  title={Binding of doxorubicin-conjugated transferrin to U937 cells.},
  author={V Sz{\"u}ts and Alajos B{\'e}rczi and E. Schweinzer and Hans Goldenberg},
  journal={Journal of receptor research},
  volume={13 7},
Binding of transferrin (Trf) and its doxorubicin-conjugated forms (Conj) to U937 cells at 0 degrees C were compared using 125I-labelled Trf or Conj. The apparent binding affinity (Ka) of Conj to the surface of U937 cells was (1.9 +/- 0.4).10(8) l/mol; it is about 40% of that of Trf [(5.0 +/- 1.2).10(8) l/mol]. Binding of 125I-labelled ligands was blocked by… CONTINUE READING