Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).


The polycomb repressive complex 2 (PRC2) is the major methyltransferase for H3K27 methylation, a modification critical for maintaining repressed gene expression programs throughout development. It has been previously shown that PRC2 maintains histone methylation patterns during DNA replication in part through its ability to bind to H3K27me3. However, the… (More)
DOI: 10.1073/pnas.1008937107


3 Figures and Tables