Binding of cytokines to pharmaceutically prepared human immunoglobulin.

@article{Svenson1993BindingOC,
  title={Binding of cytokines to pharmaceutically prepared human immunoglobulin.},
  author={Morten Svenson and Malene Breusch Hansen and Klaus Bendtzen},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 5},
  pages={
          2533-9
        }
}
Pharmaceutically prepared IgG, pooled from sera of over 2,000 normal individuals, contained both monomeric and dimeric IgG. Each type of IgG bound 125I-labeled interleukin (IL)-1 alpha, IL-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha. Increased binding to IgG was observed if 125I-IL-1 beta was denatured by heating to 39 degrees C. However, the binding of both nondenatured and denatured 125I-IL-1 beta was not inhibited by unlabeled IL-1 beta. In contrast, binding of 125I-IL-1 alpha, 125I… CONTINUE READING
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