Binding of cationic alpha-helical peptides to plasmid DNA and their gene transfer abilities into cells.

@article{Niidome1997BindingOC,
  title={Binding of cationic alpha-helical peptides to plasmid DNA and their gene transfer abilities into cells.},
  author={Takuro Niidome and Naoya Ohmori and Akitada Ichinose and Akihiro Wada and Hisaaki Mihara and Toshiya Hirayama and Haruhiko Aoyagi},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 24},
  pages={15307-12}
}
Polycationic reagents such as cationic lipids and poly-L-lysine are widely used for gene transfer into cells in vitro and show promise as vectors for in vivo gene therapy applications as nonviral gene transfer techniques. We have developed a novel transfection method using cationic amphiphilic alpha-helical oligopeptides with repeated sequences. Oligopeptide has the advantages of being easily designed and modified because of its simple structure. In this study, we synthesized five kinds of… CONTINUE READING

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