Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation.

@article{Turko1998BindingOC,
  title={Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation.},
  author={Illarion V Turko and Sharron H. Francis and Jackie D. Corbin},
  journal={The Biochemical journal},
  year={1998},
  volume={329 ( Pt 3)},
  pages={505-10}
}
cGMP-binding phosphodiesterases contain two homologous allosteric cGMP-binding sites (sites a and b) that are arranged in tandem; they constitute a superfamily of mammalian cyclic nucleotide receptors distinct from the cyclic nucleotide-dependent protein kinases/cation channels family. The functional role of each of these two sites in the phosphodiesterases… CONTINUE READING