Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

@article{Yaar1997BindingOB,
  title={Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.},
  author={Mina Yaar and Sen Zhai and Paul F Pilch and Shannon M. Doyle and Patricia B. Eisenhauer and Richard E. Fine and Barbara A. Gilchrest},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 9},
  pages={2333-40}
}
Alzheimer's disease is a neurodegenerative disorder characterized by the extracellular deposition in the brain of aggregated beta-amyloid peptide, presumed to play a pathogenic role, and by preferential loss of neurons that express the 75-kD neurotrophin receptor (p75NTR). Using rat cortical neurons and NIH-3T3 cell line engineered to stably express p75NTR, we find that the beta-amyloid peptide specifically binds the p75NTR. Furthermore, 3T3 cells expressing p75NTR, but not wild-type control… CONTINUE READING
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