Binding of benzyl penicilloyl to human serum albumin. Evidence for a highly reactive region at the junction of domains 1 and 2 of the albumin molecule.

@article{Yvon1989BindingOB,
  title={Binding of benzyl penicilloyl to human serum albumin. Evidence for a highly reactive region at the junction of domains 1 and 2 of the albumin molecule.},
  author={Mireille Yvon and Patricia Anglade and Jean Michel Wal},
  journal={FEBS letters},
  year={1989},
  volume={247 2},
  pages={273-8}
}
Tryptic digests of fragment C124-298 of penicilloylated serum albumin, obtained from a penicillin-treated patient or prepared by in vitro conjugation, were analyzed by HPLC. Determinations of benzyl penicilloyl groups (BPO) were performed on the different fractions. Three BPO-containing peptides were identified by their amino acid sequence and the bound BPO was located on lysines 190, 195 and 199 and serine 193. These four main BPO-binding sites are all located on a very short region (10 amino… CONTINUE READING

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