Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin.

@article{Bourassa2011BindingOA,
  title={Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin.},
  author={P. Bourassa and S. Dubeau and Ghulam M. Maharvi and A. Fauq and T. Thomas and H. Tajmir-Riahi},
  journal={Biochimie},
  year={2011},
  volume={93 7},
  pages={
          1089-101
        }
}
Tamoxifen is extensively metabolized, and several metabolites have been detected in human serum. The aim of this study was to examine the interaction of human serum albumin (HSA) with tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen at physiological conditions, using constant protein concentration and various drug contents. FTIR, UV-Visible, CD and fluorescence spectroscopic methods as well as molecular modeling were used to analyse drug binding mode, the binding constant and the… Expand
Cytotoxicity and comparative binding mechanism of piperine with human serum albumin and α-1-acid glycoprotein
Comprehensive insight into the binding of sunitinib, a multi-targeted anticancer drug to human serum albumin.
Human serum albumin stability and toxicity of anthraquinone dye alizarin complexone: an albumin-dye model.
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