Binding of antidepressants to human brain receptors: focus on newer generation compounds

  title={Binding of antidepressants to human brain receptors: focus on newer generation compounds},
  author={Bernadette Cusack and Albert Nelson and Elliott Richelson},
Using radioligand binding assays and postmortem normal human brain tissue, we obtained equilibrium dissociation constants (Kds) for 17 antidepressants and two of their metabolites at histamine H1, muscarinic, α1-adrenergic, α2-adrenergic, dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2 receptors. Several newer antidepressants were compared with older drugs. In addition, we studied some antimuscarinic, antiparkinson, antihistamine, and neuroleptic compounds at some of these receptors. For the… 

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