Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4.

@article{Kreimann2014BindingOA,
  title={Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4.},
  author={Martin Kreimann and Sven Brandt and Krystin Krauel and Stephan Block and Christiane A. Helm and Werner Weitschies and Andreas Greinacher and Mihaela Delcea},
  journal={Blood},
  year={2014},
  volume={124 15},
  pages={2442-9}
}
The chemokine platelet factor 4 (PF4) undergoes conformational changes when complexing with polyanions. This can induce the antibody-mediated adverse drug effect of heparin-induced thrombocytopenia (HIT). Understanding why the endogenous protein PF4 becomes immunogenic when complexing with heparin is important for the development of other negatively charged drugs and may also hint toward more general mechanisms underlying the induction of autoantibodies to other proteins. By circular dichroism… CONTINUE READING
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