Binding of anti-Z-DNA antibodies in quiescent and activated lymphocytes: relationship to cell cycle progression and chromatin changes.

@article{StaianoCoico1985BindingOA,
  title={Binding of anti-Z-DNA antibodies in quiescent and activated lymphocytes: relationship to cell cycle progression and chromatin changes.},
  author={Lisa Staiano-Coico and B. David Stollar and Zbigniew Darzynkiewicz and R T Dutkowski and Marc E. Weksler},
  journal={Molecular and cellular biology},
  year={1985},
  volume={5 11},
  pages={
          3270-3
        }
}
Although regions of DNA reacting with anti-Z-DNA antibodies have been identified in the polytene chromosomes of Drosophila spp. and the metaphase chromosomes from a number of different mammalian species, the biological role of this DNA is unknown. Flow cytometry was used in the present studies to quantitate the binding of anti-Z-DNA antibodies in quiescent and activated human peripheral blood lymphocytes; the antibody binding was then correlated with cell cycle phase. The data show that… CONTINUE READING