Binding of aminoglycoside antibiotics by degranulating mast cells.

@article{Decorti1997BindingOA,
  title={Binding of aminoglycoside antibiotics by degranulating mast cells.},
  author={Giuliana Decorti and Luigi Candussio and Fiora Bartoli Klugmann and Luca Baldini},
  journal={Chemotherapy},
  year={1997},
  volume={43 1},
  pages={36-42}
}
The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was induced by treating the cells with… CONTINUE READING