Binding of amino beta-lactam antibiotics to soluble protein from rat intestinal mucosa--II. Mutual inhibition of binding among amino beta-lactam antibiotics and binding characteristics.

@article{Iseki1987BindingOA,
  title={Binding of amino beta-lactam antibiotics to soluble protein from rat intestinal mucosa--II. Mutual inhibition of binding among amino beta-lactam antibiotics and binding characteristics.},
  author={Ken Iseki and K Mori and K Miyazaki and T. Arita},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 11},
  pages={
          1843-6
        }
}
The characteristics of binding of amino beta-lactam antibiotics including ampicillin, amoxicillin, cephalexin and cephradine to fraction b obtained from the 105,000 g supernatant of rat small intestinal mucosa was investigated. The mutual inhibition of binding among these antibiotics was observed, and these were dependent on the concentration of inhibitors. It was found that dipeptides such as L-carnosine and glycylglycine significantly reduced the binding of cephalexin to fraction b, but the… 
6 Citations
Comparison of Transport Characteristics of Amino β‐Lactam Antibiotics and Dipeptides Across Rat Intestinal Brush Border Membrane
TLDR
The results suggest that the contribution of the inward H+ gradient to the permeation of ampicillin, cephradine and glycylglycine across the rat small intestinal brush border membranes is different for each of the substances examined.
Intestinal Absorption Mechanisms of β-Lactam Antibiotics
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It is found that the mechanisms which induce secretory-oriented permeation of orally inactive β-lactam antibiotics are factors limiting intestinal absorption of such antibiotics, and the role of the binding factor, fraction b, for intestinal absorption mechanisms should be evaluated in more detail.
Effect of Chlorpromazine on the Permeability of β‐Lactam Antibiotics Across Rat Intestinal Brush Border Membrane Vesicles
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It is suggested that the two groups, drugs and actively transported substances, have a different permeation process and an increase of membrane surface fluidity might affect the permeation of β‐lactam antibiotics and actively transporting substances in a different manner.
Exploitation of the Intestinal Oligopeptide Transporter to Enhance Drug Absorption
AbstractStudies of the mechanisms involved in the transport of di- and tri-peptides by the intestinal oligopeptide transporter suggest a process which involves proton-dependent uptake at the apical
The intestinal peptide carrier: A potential transport system for small peptide derived drugs
Abstract Several laboratories have recently shown that many peptides and peptide-type drugs are absorbed in the small intestine via the peptide transporter for nutrient di-and tripeptides. The
Contribution of Passive Transport Mechanisms to the Intestinal Absorption of β‐Lactam Antibiotics
TLDR
Results suggest that the β‐lactam antibiotics tested, like L‐glucose, pass through the rat intestinal brush border membrane mainly by passive diffusion, however, the differences in absorption between these drugs cannot be explained by a simple permeation process alone.

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