Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.

@article{Fraser2006BindingOA,
  title={Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.},
  author={M. Fraser and M. Cherney and P. Marcato and G. Mulvey and G. Armstrong and M. James},
  journal={Acta crystallographica. Section F, Structural biology and crystallization communications},
  year={2006},
  volume={62 Pt 7},
  pages={
          627-30
        }
}
  • M. Fraser, M. Cherney, +3 authors M. James
  • Published 2006
  • Chemistry, Medicine
  • Acta crystallographica. Section F, Structural biology and crystallization communications
Stx2 is a protein toxin whose catalytic subunit acts as an N-glycosidase to depurinate a specific adenine base from 28S rRNA. In the holotoxin, the catalytic portion, A1, is linked to the rest of the A subunit, A2, and A2 interacts with the pentameric ring formed by the five B subunits. In order to test whether the holotoxin is active as an N-glycosidase, Stx2 was crystallized in the presence of adenosine and adenine. The crystals diffracted to approximately 1.8 angstroms and showed clear… Expand
Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.
Do the A Subunits Contribute to the Differences in the Toxicity of Shiga Toxin 1 and Shiga Toxin 2?
Shiga Toxin (Stx) Classification, Structure, and Function.
Shiga Toxin (Stx) Classification, Structure, and Function.
Ricin and Shiga Toxins
  • N. Mantis
  • Chemistry
  • Current Topics in Microbiology and Immunology
  • 2012
Interaction of ricin and Shiga toxins with ribosomes.
Small-molecule inhibitors of ricin and Shiga toxins.
...
1
2
3
...

References

SHOWING 1-10 OF 22 REFERENCES
Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli
X-ray structure of recombinant ricin A-chain at 1.8 A resolution.
Subunit structure of Shigella cytotoxin.
Vero response to a cytotoxin of Escherichia coli.
...
1
2
3
...