Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

@article{Montminy1987BindingOA,
  title={Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene},
  author={Marc Montminy and Louise M. Bilezikjian},
  journal={Nature},
  year={1987},
  volume={328},
  pages={175-178}
}
Many hormones act on neuroendocrine cells by activating second messenger pathways. Two of these, the phosphoinositol and cAMP-dependent pathways, cause changes in cellular activity through specific protein kinases. By phosphorylating cytoplasmic and nuclear proteins, these kinases apparently coordinate cellular processes, including the biosynthesis and release of neuropeptides. Somatostatin biosynthesis and release, for example, are both positively regulated by the second messenger cAMP in… Expand
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