Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation.

@article{Andersson2001BindingOA,
  title={Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation.},
  author={Jonas L. Andersson and Rolf Larsson and Rudolf Richter and Kristina Nilsson Ekdahl and Bo N Nilsson},
  journal={Biomaterials},
  year={2001},
  volume={22 17},
  pages={2435-43}
}
The complement system is an important inflammatory mediator during procedures such as cardiopulmonary bypass and hemodialysis when blood is exposed to large areas of biomaterial surface. This contact between blood and the biomaterials of implants and extracorporeal circuits leads to an inflammatory response mediated by the complement system. The aim of this study was to assess the ability of a complement regulator (factor H) immobilised on a biomaterial surface to inhibit complement cascade… CONTINUE READING

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