Binding of a cellular factor to the 3' untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication.

@article{Mellits1998BindingOA,
  title={Binding of a cellular factor to the 3' untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication.},
  author={Kenneth H Mellits and Janet M. Meredith and Jonathan B Rohll and David W Evans and Jeffrey W. Almond},
  journal={The Journal of general virology},
  year={1998},
  volume={79 ( Pt 7)},
  pages={1715-23}
}
The presence of cellular factors that bind to the 3' untranslated region (UTR) of picornaviruses was investigated by electrophoretic mobility shift assays (EMSAs). A cellular factor(s) that binds specifically the 3' UTR of polio-, coxsackie- and rhinoviruses was detected. Furthermore, this factor(s) is distinct from those which bind to the 5' terminal 88 nt (the 'cloverleaf') of poliovirus. Mutations within the 3' UTR which decrease the affinity of the RNA for the cellular factor in EMSAs… CONTINUE READING

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