Binding of Translationally Controlled Tumour Protein to the N-Terminal Domain of HDM2 Is Inhibited by Nutlin-3

@inproceedings{Funston2012BindingOT,
  title={Binding of Translationally Controlled Tumour Protein to the N-Terminal Domain of HDM2 Is Inhibited by Nutlin-3},
  author={Garth Funston and Walter L P Goh and Siau Jia Wei and Quah Soo Tng and Christopher Brown and Loh Jiah Tong and Chandra Verma and David Lane and Farid J Ghadessy},
  booktitle={PloS one},
  year={2012}
}
Translationally Controlled Tumour Protein (TCTP), a highly conserved protein present in all eukaryotic organisms, has a number of intracellular and extracellular functions including an anti-apoptotic role. TCTP was recently shown to interact with both p53 and HDM2, inhibiting auto-ubiquitination of the latter and thereby promoting p53 degradation. In this study, we further investigated the interaction between TCTP and HDM2, mapping the reciprocal binding sites of TCTP and HDM2. TCTP primarily… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
6 Extracted Citations
33 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 33 references

Role of the translationally controlled tumor protein in DNA damage sensing and repair

  • J Zhang, SM de Toledo, BN Pandey, G Guo, D Pain
  • Proc Natl Acad Sci U S A
  • 2012

Similar Papers

Loading similar papers…