Binding of Salmonella typhimurium lipopolysaccharides to rat high-density lipoproteins.

@article{Munford1981BindingOS,
  title={Binding of Salmonella typhimurium lipopolysaccharides to rat high-density lipoproteins.},
  author={Robert S. Munford and Catherine Hall and John M. Dietschy},
  journal={Infection and immunity},
  year={1981},
  volume={34 3},
  pages={835-43}
}
These studies were undertaken to investigate the binding of gram-negative bacterial lipopolysaccharides (LPS) to high-density lipoproteins (HDL) of rat plasma. Purified Salmonella typhimurium LPS, intrinsically labeled with [3H]-galactose, bound rapidly in vitro to isolated rat HDL. Maximal binding of LPS to HDL occurred when LPS and HDL were incubated with lipoprotein-free plasma (rho greater than 1.21 g/ml). Since LPS, when purified, form large aggregates, we tested the hypothesis that… CONTINUE READING