Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

@article{Kurzer2006BindingOS,
  title={Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.},
  author={Jason H Kurzer and Pipsa Saharinen and Olli Silvennoinen and Christin Carter-Su},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 17},
  pages={6381-94}
}
The tyrosine kinase Janus kinase 2 (JAK2) transduces signaling for the majority of known cytokine receptor family members and is constitutively activated in some cancers. Here we examine the mechanisms by which the adapter proteins SH2-Bbeta and APS regulate the activity of JAK2. We show that like SH2-Bbeta, APS binds JAK2 at multiple sites and that binding to phosphotyrosine 813 is essential for APS to increase active JAK2 and to be phosphorylated by JAK2. Binding of APS to a phosphotyrosine… CONTINUE READING