Binding of Rab3A to synaptic vesicles.

  title={Binding of Rab3A to synaptic vesicles.},
  author={Judy H. Chou and Renate Jahn},
  journal={The Journal of biological chemistry},
  volume={275 13},
Prenylated Rab GTPases cycle between membrane-bound and soluble forms. Membrane-bound GDP-Rabs interact with GDP dissociation inhibitor (GDI), resulting in the dissociation of a Rab.GDI complex, which in turn serves as a precursor for the membrane re-association of Rabs. We have now characterized the binding of Rab3A to synaptic vesicles in vitro using either purified complexes or rat brain cytosol as source for GDI.Rab3A. Binding of Rab3A results in the immediate release of GDI from the… CONTINUE READING
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