Binding of Platelets to Lymphocytes: A Potential Anti-Inflammatory Therapy in Rheumatoid Arthritis.

@article{Zamora2017BindingOP,
  title={Binding of Platelets to Lymphocytes: A Potential Anti-Inflammatory Therapy in Rheumatoid Arthritis.},
  author={Carlos Zamora and Eliseo Garc{\'i}a Cant{\'o} and Juan Camilo Nieto and Jorge E. Bardina and C{\`e}sar D{\'i}az-Torn{\'e} and Patricia Cham{\'o}n Moya and B Lόpez Magallares and Maria Dels Angels Ortiz and Grigorieva Julia and Candido Juarez and Josep Maria Llobet and S{\'i}lvia Vidal},
  journal={Journal of immunology},
  year={2017},
  volume={198 8},
  pages={
          3099-3108
        }
}
Soluble factors released from platelets can modulate the immune response of leukocytes. We and others have recently found that T lymphocytes with bound platelets have reduced proliferation and IFN-γ and IL-17 production. Thus, we speculate that if we induce the binding of platelets to lymphocytes, we will be able to regulate the inflammatory response. When we cocultured platelets with lymphocytes at different ratios, we were able to increase the percentage of lymphocytes with bound platelets… CONTINUE READING
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