Binding of Plasmodium falciparum 175-kilodalton erythrocyte binding antigen and invasion of murine erythrocytes requires N-acetylneuraminic acid but not its O-acetylated form.

@article{Klotz1992BindingOP,
  title={Binding of Plasmodium falciparum 175-kilodalton erythrocyte binding antigen and invasion of murine erythrocytes requires N-acetylneuraminic acid but not its O-acetylated form.},
  author={F W Klotz and Palmer A. Orlandi and Gerd Reuter and Sheftel J Cohen and J. David Haynes and Roland Schauer and Russell J. Howard and P. Palese and Louis H. Miller},
  journal={Molecular and biochemical parasitology},
  year={1992},
  volume={51 1},
  pages={49-54}
}
Sialic acid on human erythrocytes is involved in invasion by the human malaria parasite, Plasmodium falciparum. Mouse erythrocytes were used as a reagent to explore the question of whether erythrocyte sialic acid functions as a nonspecific negative charge or whether the sialic acid is a necessary structural part of the receptor for merozoites. Human erythrocytes contain N-acetylneuraminic acid (Neu5Ac), whereas mouse erythrocytes, which are also invaded by P. falciparum merozoites, contain 9-O… CONTINUE READING

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