Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis.

@article{Vicentini1994BindingOP,
  title={Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis.},
  author={Adriana Pardini Vicentini and Jean Luc Gesztesi and Marcelo Franco and Wanderley de Souza and Jane Zveiter de Moraes and Luiz R Travassos and Jos{\'e} Daniel Lopes},
  journal={Infection and immunity},
  year={1994},
  volume={62 4},
  pages={1465-9}
}
Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion. This was confirmed by binding assays using purified gp43, with a Kd of 3.7 nM. The coating of P. brasiliensis yeast forms with laminin before injection into hamster testicles enhanced the… CONTINUE READING

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