Binding of Multivalent Ligands to Cells: E ects of Cell and Receptor Density Condensed title: Binding of Multivalent Ligands (Keywords: Multivalent Ligands, Crosslinking Receptor Density, Fc Receptor)

@inproceedings{Sulzer2007BindingOM,
  title={Binding of Multivalent Ligands to Cells: E ects of Cell and Receptor Density Condensed title: Binding of Multivalent Ligands (Keywords: Multivalent Ligands, Crosslinking Receptor Density, Fc Receptor)},
  author={B. Sulzer},
  year={2007}
}
We study the equilibrium binding properties of multivalent ligands and mixtures of ligands of diierent valence to cell surface receptors. We examine the eeects of changing cell density or number of receptors per cell, i.e., receptor concentration, over a wide but physiologically relevant range. Qualitatively diierent behaviour arises in the excess receptor regime, where the volume concentration of receptors is much greater than the ligand concentration, and the excess ligand regime, where the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Molecular determinants of immunogenicity: the immunon model of immune response.

Proceedings of the National Academy of Sciences of the United States of America • 1976
View 4 Excerpts
Highly Influenced

Some mathematical models of receptor clustering by multivalent ligands

A. S. Perelson
1984
View 7 Excerpts
Highly Influenced

The binding of multivalent ligands to cell

S. K. Dower, J. A. Titus, D. M. Segal
1984
View 7 Excerpts
Highly Influenced

Receptor clustering on a cell surface

A. S. Perelson, C. DeLisi.
I. Theory of receptor • 1980
View 9 Excerpts
Highly Influenced

A theory of antibody-antigen reactions

R. J. Goldberg
I. Thery for reactions of multivalent • 1952
View 4 Excerpts
Highly Influenced

Human IgG Fc receptor

J.G.J. van de Winkel, P.J.A. Capel
1993
View 1 Excerpt

Fc receptors.

Annual review of immunology • 1991
View 1 Excerpt