Binding of LL-37 to model biomembranes: insight into target vs host cell recognition.

@article{Sood2008BindingOL,
  title={Binding of LL-37 to model biomembranes: insight into target vs host cell recognition.},
  author={Rohit Sood and Yegor A Domanov and Milla Pieti{\"a}inen and Vesa P. Kontinen and Paavo K. J. Kinnunen},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 4},
  pages={983-96}
}
Pursuing the molecular mechanisms of the concentration dependent cytotoxic and hemolytic effects of the human antimicrobial peptide LL-37 on cells, we investigated the interactions of this peptide with lipids using different model membranes, together with fluorescence spectroscopy for the Trp-containing mutant LL-37(F27W). Minimum concentrations inhibiting bacterial growth and lipid interactions assessed by dynamic light scattering and monolayer penetration revealed the mutant to retain the… CONTINUE READING

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