Binding of L-selectin to the vascular sialomucin CD34.

@article{Baumheter1993BindingOL,
  title={Binding of L-selectin to the vascular sialomucin CD34.},
  author={S Baumheter and Mark S. Singer and William Henzel and Stefan Hemmerich and Mark E. Renz and S D Rosen and Laurence A. Lasky},
  journal={Science},
  year={1993},
  volume={262 5132},
  pages={
          436-8
        }
}
The adhesive interactions between leukocyte L-selectin and the endothelium are involved in the migration of lymphocytes through peripheral lymph nodes and of neutrophils to sites of inflammation. A recombinant L-selectin stains high endothelial venules (HEVs) in lymph nodes and recognizes sulfated carbohydrates found on two endothelial glycoproteins, Sgp50 and Sgp90. Amino acid sequencing of purified Sgp90 revealed a protein core identical to that CD34, a sialomucin expressed on hematopoietic… CONTINUE READING
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