Binding of IgG-opsonized particles to Fc gamma R is an active stage of phagocytosis that involves receptor clustering and phosphorylation.

Abstract

Fc gammaR mediate the phagocytosis of IgG-coated particles and the clearance of IgG immune complexes. By dissecting binding from internalization of the particles, we found that the binding stage, rather than particle internalization, triggered tyrosine phosphorylation of Fc gammaR and accompanying proteins. High amounts of Lyn kinase were found to associate… (More)

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Cite this paper

@article{Sobota2005BindingOI, title={Binding of IgG-opsonized particles to Fc gamma R is an active stage of phagocytosis that involves receptor clustering and phosphorylation.}, author={Andrzej Sobota and Agnieszka Strzelecka-Kiliszek and Ewelina Gładkowska and Kiyotsugu Yoshida and Kazimiera Mrozińska and Katarzyna Kwiatkowska}, journal={Journal of immunology}, year={2005}, volume={175 7}, pages={4450-7} }