Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.

@article{McDougal1986BindingOH,
  title={Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.},
  author={J. Steven McDougal and M. Susan Kennedy and J M Sligh and S P Cort and Alison C. Mawle and Janet K. A. Nicholson},
  journal={Science},
  year={1986},
  volume={231 4736},
  pages={382-5}
}
Human T-lymphotropic virus type III (HTLV-III) or lymphadenopathy-associated virus (LAV) is tropic for human T cells with the helper-inducer phenotype, as defined by reactivity with monoclonal antibodies specific for the T4 molecule. Treatment of T4+ T cells with monoclonal antibodies to T4 antigen blocks HTLV-III/LAV binding, syncytia formation, and infectivity. Thus, it has been inferred that the T4 molecule itself is a virus receptor. In the present studies, the surfaces of T4+ T cells were… CONTINUE READING