Binding of HMG‐I(Y) elicits structural changes in a silencer of the human β‐globin gene

@article{Chase1999BindingOH,
  title={Binding of HMG‐I(Y) elicits structural changes in a silencer of the human $\beta$‐globin gene},
  author={Michael B. Chase and Susanne B. Haga and W. David Hankins and Donna M. Williams and Zhigang Bi and Jeffrey W. Strovel and Christine Obriecht and Patricia E. Berg},
  journal={American Journal of Hematology},
  year={1999},
  volume={60}
}
Proteins involved in repression of the human β‐globin gene may be useful in the treatment of sickle cell anemia, in conjunction with therapy to reactivate fetal globin genes. If there is a reciprocal elevation of β‐globin expression upon repression, this approach could be useful in additional hemoglobinopathies. We previously showed that repression of the β‐globin gene appears to be mediated through two DNA sequences, silencers I and II, and identified a protein termed BP1 which binds to both… Expand
BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene
ABSTRACT In earlier studies we identified a putative repressor of the human β-globin gene, termed beta protein 1 (BP1), which binds to two silencer DNA sequences upstream of the adult human β-globinExpand
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