Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments.

@article{Cheng2012BindingOH,
  title={Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments.},
  author={Kai Cheng and Kheireddine El-Boubbou and Christopher C Landry},
  journal={ACS applied materials & interfaces},
  year={2012},
  volume={4 1},
  pages={235-43}
}
An important step in human immunodeficiency virus infection involves the interaction between the viral envelope glycoprotein gp120 and the human host cell surface receptor CD4. Herein, we describe a CD4-functionalized mesoporous silica-based system to selectively capture HIV-gp120 with high binding efficiency. Using a protection-deprotection strategy developed recently by our group, the external surface of the mesoporous particles was selectively functionalized with soluble CD4 ("sCD4") or an… CONTINUE READING
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