Binding of Divalent Cations to Insulin: Capillary Electrophoresis and Molecular Simulations.

@article{DubouDijon2018BindingOD,
  title={Binding of Divalent Cations to Insulin: Capillary Electrophoresis and Molecular Simulations.},
  author={Elise Dubou{\'e}-Dijon and Pauline Delcroix and Hector Martinez-Seara and Jana Hlad{\'i}lkov{\'a} and Pavel Coufal and Tom{\'a}{\vs} Kř{\'i}{\vz}ek and Pavel Jungwirth},
  journal={The journal of physical chemistry. B},
  year={2018},
  volume={122 21},
  pages={
          5640-5648
        }
}
In the present study, we characterize the binding of divalent cations to insulin in aqueous salt solutions by means of capillary electrophoresis and molecular dynamics simulations. The results show a strong pH dependence. At low pH, at which all the carboxylate groups are protonated and the protein has an overall positive charge, all the cations exhibit only weak and rather unspecific interactions with insulin. In contrast, at close to neutral pH, when all the carboxylate groups are… CONTINUE READING
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