Binding of Ca2+ and Na+ to sarcolemmal membranes: relation to control of myocardial contractility.

Studies are presented that relate the calcium binding of isolated sarcolemmal membranes to myocardial contractility. The contractile strength of the perfused rabbit interventricular septum as a function of perfusate calcium concentration is compared with calcium bound to isolated rabbit sarcolemma at the same calcium concentrations. If the calcium-binding… CONTINUE READING