Binding of C4b-Binding Protein to Porin

@article{Ram2001BindingOC,
  title={Binding of C4b-Binding Protein to Porin},
  author={Sanjay Ram and Meabh Cullinane and Anna M. Blom and Sunita Gulati and Daniel P. McQuillen and Brian G Monks and Catherine M O'Connell and Ryan Boden and Christopher Elkins and Michael S. Pangburn and Bj{\"o}rn Dahlb{\"a}ck and Peter A. Rice},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={193},
  pages={281 - 296}
}
We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp). Microbial surface-bound C4bp demonstrated cofactor activity. We constructed gonococcal strains with hybrid porin (Por) molecules derived from each of the major serogroups (Por1A and Por1B) of N. gonorrhoeae, and showed that the loop 1 of Por1A is required for C4bp binding. Por1B loops… CONTINUE READING

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