Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein.

@article{Taskinen2002BindingOC,
  title={Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein.},
  author={Sanna Taskinen and Petri T. Kovanen and Hanna Jarva and Seppo Meri and Markku O. Pentik{\"a}inen},
  journal={The Biochemical journal},
  year={2002},
  volume={367 Pt 2},
  pages={403-12}
}
C-reactive protein (CRP), an acute-phase reactant, is present in atherosclerotic human arterial intima in association with lipids. In the present work we studied interactions between CRP and LDL on microtitre wells, where either CRP or LDL was immobilized. LDL was modified by vortex-mixing, oxidation, or by lipolysis with phospholipase A(2) or with sphingomyelinase or a combination of trypsin and cholesterol esterase. We found that CRP bound only to LDL modified by trypsin/cholesterol esterase… CONTINUE READING