Binding of ATP to vascular endothelial growth factor isoform VEGF-A165 is essential for inducing proliferation of human umbilical vein endothelial cells

@inproceedings{Gast2010BindingOA,
  title={Binding of ATP to vascular endothelial growth factor isoform VEGF-A165 is essential for inducing proliferation of human umbilical vein endothelial cells},
  author={Ronald E Gast and Simone K{\"o}nig and Karsten Rose and Katja Bettina Ferenz and Josef Krieglstein},
  booktitle={BMC Biochemistry},
  year={2010}
}
ATP binding is essential for the bioactivity of several growth factors including nerve growth factor, fibroblast growth factor-2 and brain-derived neurotrophic factor. Vascular endothelial growth factor isoform 165 (VEGF-A165) induces the proliferation of human umbilical vein endothelial cells, however a dependence on ATP-binding is currently unknown. The aim of the present study was to determine if ATP binding is essential for the bioactivity of VEGF-A165. We found evidence that ATP binding… CONTINUE READING