Binding of AP2 to sorting signals is modulated by AP2 phosphorylation.

  title={Binding of AP2 to sorting signals is modulated by AP2 phosphorylation.},
  author={Andy Fingerhut and Kurt von Figura and Stephan Honing},
  journal={The Journal of biological chemistry},
  volume={276 8},
The two clathrin-associated adaptor complexes AP1 and AP2 are known to participate in the formation of clathrin-coated vesicles at the trans-Golgi network and at the plasma membrane. During this process adaptors are involved in the sequestration of vesicle cargo by binding to the sorting signals within the cytoplasmic domains of the cargo proteins and in the recruitment of the clathrin coat. After budding of the clathrin-coated vesicles, the clathrin and adaptors dissociate from the vesicles… CONTINUE READING


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