Binding of 5,9-dimethyl dibenzo[c,g]carbazole, a potent hepatocarcinogen, to mouse hepatic cytosolic proteins.

Abstract

5,9-Dimethyl dibenzo[c,g]carbazole (5,9-diMe DBC) is a powerful organ-specific liver carcinogen in mice. Its binding to liver cytosolic proteins has been studied in vivo and in vitro with the aid of a tritium-labelled sample. Only two classes of proteins fractionated on Sephadex G100 appear to be involved in this binding: one class of high mol. wt. proteins… (More)

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