Binding of [3H]Haloperidol to Dopamine D2 Receptors in the Rat Striatum

  title={Binding of [3H]Haloperidol to Dopamine D2 Receptors in the Rat Striatum},
  author={H. Tsuchihashi and T. Sasaki and S. Kojima and T. Nagatomo},
  journal={Journal of Pharmacy and Pharmacology},
Abstract— The present study was designed to examine the properties of [3H]haloperidol binding to dopamine D2‐receptors in rat striatum membranes, displacement potencies of various chemicals and differences between the affinities of various chemicals and two new 5‐hydroxytryptamine (5‐HT2) receptor antagonists, MCI‐9042, (±)‐2‐(dimethylamino)‐1‐[[o‐(m‐methoxyphenetyl)phenoxy]methyl]ethyl hydrogen succinate hydrochloride and one of its metabolites. The plots of specific binding for the striatum… Expand
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