Binding investigation of integrin alphavbeta3 with its inhibitors by SPR technology and molecular docking simulation.

Abstract

Integrins play critical roles in the process of angiogenesis and are attractive targets for anticancer therapies. It is desirable to develop new types of small-molecule inhibitors of integrin. Herein, the binding features of several inhibitors to integrin alpha(v)beta(3) have been studied by surface plasmon resonance (SPR) biosensor technology and molecular… (More)
DOI: 10.1177/1087057109356207

Topics

8 Figures and Tables