Binding interactions between soluble HIV envelope glycoproteins and quaternary-structure-specific monoclonal antibodies PG9 and PG16.

@article{Davenport2011BindingIB,
  title={Binding interactions between soluble HIV envelope glycoproteins and quaternary-structure-specific monoclonal antibodies PG9 and PG16.},
  author={Thaddeus M. Davenport and Della Friend and Katharine Ellingson and Hengyu Xu and Zachary R Caldwell and George E Sellhorn and Zane Kraft and Roland K. Strong and Leonidas Stamatatos},
  journal={Journal of virology},
  year={2011},
  volume={85 14},
  pages={7095-107}
}
PG9 and PG16 are antibodies isolated from a subject infected with HIV-1 and display broad anti-HIV neutralizing activities. They recognize overlapping epitopes, which are preferentially expressed on the membrane-anchored trimeric form of the HIV envelope glycoprotein (Env). PG9 and PG16 were reported not to bind to soluble mimetics of Env. The engineering of soluble Env proteins on which the PG9 and PG16 epitopes are optimally exposed will support efforts to elicit broad anti-HIV neutralizing… CONTINUE READING
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